摘要
目的:探讨CD44v6和MMP-9在胃癌组织中的表达及其与肿瘤浸润转移的关系。方法:应用免疫组化SP双染技术检测CD44v6和MMP-9在60例原发性胃癌及60例癌旁正常胃组织中的表达情况,分析其在胃癌组织中的表达与临床病理特征之间的关系以及两者在胃癌浸润转移过程中的相关关系。结果:胃癌组织中CD44v6和MMP-9蛋白的表达均高于癌旁正常胃组织(χ2配对=36.393和44.083,P<0.001)。CD44v6和MMP-9蛋白的表达与胃癌的浸润深度(χ2=10.899和11.129,P<0.05)、TNM分期(χ2=8.102和6.376,P<0.05)有关,与患者的性别、年龄、肿瘤直径、淋巴结转移及生长的部位无关(P>0.05)。CD44v6和MMP-9蛋白在胃癌中的表达呈正关联(rS=0.036,P=0.009)。结论:CD44v6和MMP-9在胃癌组织中阳性表达可能在肿瘤浸润及转移过程中发挥协同作用。
Aim： To investigate the relationship between the expressions of CD44v6,MMP-9 proteins in gastric cancer tissue and the invasion and metastasis of patients with gastric cancer. Methods： Using double immunohistochemisitry technique,the expressions of CD44v6 and MMP-9 in 60 cases of primary gastric cancer tissue and 60 cases of adjacent normal gastric tissues were detected,and the relationship between the expressions of CD44v6 and MMP-9 and invasion and metastasis of gastric cancer was analyzed. Results： The expressions of CD44v6 and MMP-9 proteins in gastric cancer tissue were significantly higher than those in adjacent normal gastric tissue（ χ2paired= 36. 363 and 44. 083, P〈0. 001）. Additionally,the expressions of CD44v6 and MMP-9 proteins in gastric cancer tissue were markedly related with the depth of invasion（ χ2=10. 899 and 11. 129, P〈0. 05） and TNM staging（ χ2= 8. 102 and 6. 376, P〈0. 05）,but not related with lymph node metastasis,gender,age,the size or the location of cancer（ P〈0. 05）. Moreover,the expression of CD44v6 and MMP-9 proteins in gastric cancer tissue displayed positive correlation（ rS= 0. 036,P = 0. 009）. Conclusion： The expressions of CD44v6 and MMP-9 may play a synergistic role in invasion and metastasis of gastric cancer.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2015年第3期423-426,共4页
Journal of Zhengzhou University(Medical Sciences)
作者简介
通信作者，男，1966年1月生，博士，主任医师，副教授，研究方向：消化道肿瘤基础与临床，E-mail：zhaochunlin@ZZU.edu.cn
