摘要
目的介绍微乳凝胶经皮给药制剂的研究与应用进展。方法根据近年来国内外相关文献,对微乳凝胶作为经皮给药载体的处方筛选、制备、体外释药性能、质量检查、研究应用进展等方面进行介绍。结果微乳凝胶具有显著增强药物的经皮渗透能力、降低药物刺激性和延缓药物释放等作用,且更便于给药。结论微乳凝胶有望成为一种具有重要应用价值的经皮给药新剂型。
OBJECTIVE To introduce the progress of investigation and application for microemulsion-based gels transdermal delivery system. METHODS Reviewed the domestic and international articles, to introduce the prescription screening, preparation, in vitro release, quality checks and the progress of investigation and application for microemulsion-based gels transdermal delivery system. RESULTS Microemulsion-based gels could increase penetration rate, reduce the irritation, extend the drug action time, and use easy. CONCLUSION It is suggested that microemulsion-based gels is a promising carrier for transdermal drug delivery system.
出处
《中国现代应用药学》
CAS
CSCD
2015年第6期764-768,共5页
Chinese Journal of Modern Applied Pharmacy
基金
杭州市余杭区科技计划课题(201209)
浙江省药学会医院药学专项科研基金项目(2012ZYY17)
关键词
微乳
凝胶
载体
经皮给药
microemulsion
gel
carrier
transdermal delivery system
作者简介
谢明华，男，硕士生，主管药师Tel：（0571）89369507,E-mail：xmh53072@163．com
通信作者：高建青，男，博士，教授Tel：（0571）88208437,E-mail：gaojianqing@zju．edu.cn
