摘要
背景:结直肠腺瘤性息肉与结直肠癌关系密切,是重要的癌前病变。目的:分析老年人结直肠腺瘤性息肉的临床特点。方法:选取2011年1月-2014年7月南京医科大学第一附属医院经结肠镜和病理检查证实为结直肠腺瘤性息肉的老年患者178例,对患者的性别、年龄、腺瘤部位、腺瘤大小、病理类型、异型增生、癌变等因素进行回顾性分析。结果:不同性别、年龄、大小的腺瘤分布差异无统计学意义(P>0.05)。随着腺瘤直径的增大,管状腺瘤的检出率下降,绒毛-管状腺瘤的检出率增高(P<0.01),腺上皮中重度异型增生的发生率增加,腺瘤的癌变率增加(P<0.01),且绒毛-管状腺瘤的腺上皮异型增生程度和癌变率明显高于管状腺瘤(P<0.01)。结论:随着腺瘤直径的增加,老年腺瘤性息肉患者绒毛-管状腺瘤的发生率、异型增生程度以及腺瘤癌变率均明显增加,早期发现并治疗腺瘤性息肉可有效减少老年结直肠癌的发生。
Background： It has been widely accepted that colorectal adenomatous polyp as an important premalignant lesion is closely associated with the risk of colorectal cancer. Aims： To analyze the clinical features of colorectal adenomatous polyp in elderly patients. Methods： One hundred and seventy-eight elderly patients with colorectal adenomatous polyp diagnosed by colonoscopy and pathological examination from January 2011 to July 2014 at the First Affiliated Hospital of Nanjing Medical University were enrolled,and gender,age,location,size,pathological type,dysplasia and cancerization were retrospectively analyzed. Results： No significant differences in distribution of adenomatous polyp in patients with different gender,age and size were found（ P 0. 05）. With the increase of adenomatous polyp size,the detection rate of tubular adenomatous polyp was decreased and the detection rate of tubular-villous adenomatous polyp was increased（ P 0. 01）,and incidence of moderate to severe dysplasia and cancerization rate were increased（ P 0. 01）. The degree of dysplasia and cancerization rate were higher in tubular-villous adenomatous polyp than in tubular adenomatous polyp（ P 0. 01）.Conclusions： With the increase of adenomatous polyp size,the incidence of tubular-villous adenomatous polyp,degree of dysplasia and cancerization rate are increased,early detection and treatment of adenomatous polyp can effectively reduce the incidence of colorectal cancer in elderly patients.
出处
《胃肠病学》
2015年第2期106-108,共3页
Chinese Journal of Gastroenterology
关键词
腺瘤性息肉
大肠
老年人
回顾性研究
Adenomatous Polyps
Intestine
Large
Aged
Retrospective Studies
