摘要
目的探讨不同病理分型结直肠息肉患者的肠道菌群特点。方法选取2020年1—12月北部战区总医院消化内科收治的133例结直肠息肉患者为研究对象。按照息肉组织病理学分型将患者分为腺瘤组(n=87)与非腺瘤组(n=46)。比较两组患者一般资料,革兰氏阳性球菌(G^(+)球菌)、革兰氏阳性杆菌(G^(+)杆菌)、革兰氏阴性杆菌(G^(+)杆菌)、革兰氏阴性球菌(G^(+)球菌)比例及各检验指标。结果两组患者内镜下手术方式比较,差异有统计学意义(P<0.05)。两组患者G^(+)球菌比例比较,差异有统计学意义(P<0.05)。两组患者G^(+)杆菌比例、G^(+)杆菌比例比较,差异无统计学意义(P>0.05)。腺瘤组的G^(+)球菌正常范围占32.2%(28/87),高于非腺瘤组的13.0%(6/46),差异有统计学意义(P<0.05)。非腺瘤组的G^(+)球菌比例较正常增多占76.1%(35/46),高于腺瘤组的57.5%(50/87),差异有统计学意义(P<0.05)。两组患者便转铁蛋白阳性比例比较,差异有统计学意义(P<0.05)。两组患者超敏C反应蛋白、尿素水平比较,差异有统计学意义(P<0.05)。结论结直肠息肉患者的肠道菌群G^(+)球菌比例较正常增多,G^(+)杆菌比例较正常明显增多,G^(+)杆菌比例较正常显著减少。腺瘤患者G^(+)球菌比例多处于正常范围,非腺瘤患者G^(+)球菌多处于较正常增多范围。
Objective To explore the characteristics of intestinal flora in patients with colorectal polyps with different pathological types.Methods A total of 133 patients with colorectal polyps admitted to the department of gastroenterology,General Hospital of e Northern Theater Command from January to December 2020 were selected as the research subjects.The general data,proportion of G^(+)coccus,G^(+)bacillus,G^(+)bacillus and test indexes of the two groups were compared.Results There was a statistically significant difference between two groups of patients in the way of endoscopic surgery(P<0.05).The proportion of G^(+)cocci in stool smear test of intestinal flora in two groups was statistically significant(P<0.05).There was no significant difference in the proportion of G^(+)bacillus and G^(+)bacillus between the two groups(P>0.05).The normal range of G^(+)cocci in adenoma group was 32.2%(28/87),which was higher than that in non-adenoma group(13.0%,6/46),and the difference was statistically significant(P<0.05).The proportion of G^(+)cocci in non-adenoma group was 76.1%(35/46),which was higher than that in adenoma group(57.5%,50/87),and the difference was statistically significant(P<0.05).The positive proportion of fecal transferrin in two groups was significantly different(P<0.05).There were statistically significant differences in hs-CRP and Urea between the two groups(P<0.05).Conclusion The proportion of G^(+)cocci in the intestinal flora smear of patients with colorectal polyps is higher than normal,the ratio of G^(+)bacteria is significantly higher than normal,and the ratio of G^(+)bacilli is significantly lower than normal.The proportion of G^(+)cocci in adenoma patients is mostly in the normal range,and G^(+)cocci in non-adenoma patients is mostly in the higher than normal range.
作者
罗娅媛
侯飞飞
寇文静
张宇飞
史晓丹
邵晓冬
郭晓钟
刘旭
LUO Ya-yuan;HOU Fei-fei;KOU Wen-jing;ZHANG Yu-fei;SHI Xiao-dan;SHAO Xiao-dong;GUO Xiao-zhong;LIU Xu(Graduate training base of General Hospital of Northern Theater Command of Jinzhou Medical University,Shenyang 110016,China;Department of Gastroenterology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2022年第2期152-155,159,共5页
Clinical Journal of Medical Officers
基金
辽宁省自然基金资助计划(2019-MS-352)
沈阳市科技计划项目(19-112-4-046)
关键词
结直肠息肉
肠道菌群
腺瘤
粪便涂片镜检
Colorectal polyps
Intestinal flora
Adenoma
Stool smear microscopy
作者简介
第一作者:罗娅媛(1994-),女,河南平顶山人;通信作者:刘旭,E-mail:we1980@163.com
