摘要
目的 探讨依达拉奉联合氯吡格雷治疗急性脑梗死的近期临床疗效与安全性。方法 选取急性脑梗死120例，以患者就诊顺序分为观察组与对照组，每组各60例。在急性脑梗死常规治疗的基础上，观察组增加依达拉奉和氯吡格雷，对照组增加氯吡格雷，2组均连续治疗14d。治疗前后评价神经功能、日常生活能力，记录不良反应，随访1年观察有无复发。结果 治疗后，2组肢体运动、神经、语言等功能均有程度不等的恢复。观察组与对照组的总有效率分别为93．33％和78．33％，观察组的神经功能缺损程度、生活能力评分均优于对照组，1年复发率分别为5．77％和9．26％，差异均具有统计学意义（P〈0．05）。2组均未见明显的不良反应。结论 依达拉奉联合氯吡格雷治疗急性脑梗死具有明确的疗效，能有效缓解患者的神经功能缺损，提升其日常生活能力，降低复发率，且安全性较高。
Objective To explore the short-term efficacy and safety of edaravone combined with clopidogrel in treatment of acute cerebral infarction（ACI）. Methods 120 cases of ACI were selected and they were randomly divided into the observation group（ 60 cases）and the control group according to the visiting order（ 60 cases）. On the basis of routine treatment of ACI, the control group were treated with clopidogrel, and the observation group were added with edaravone combined with clopidogrel. All patients were treated continuously for 14 days. Patients＇ neural function, activities of daily living, and adverse reactions were evaluated before and after treatment. All patients were followed up for 1 year to record recurrence. Results After treatment, patients＇ limb movements, neural functions and language had varying degrees of recovery. Total efficiency was 93.33% and 78.33% respectively for the observation group and the control group. Grading of the neurologic impairment and life ability of the observation group were both better than the control group. The one-year recurrence rate was 5.77% and 9.26% for the observation group and the control group, and the difference had statistical significance （P 〈 0. 05）. No obvious adverse reaction in the 2 groups was found. Conclusion The curative effect of edaravone combined with clopidogrel is remarkable in treating ACI, and it can remit patients＇ neurological deficit, improve their daily life ability, reduce the recurrence rate, and has high safety.
出处
《中华内分泌外科杂志》
CAS
2015年第1期38-40,55,共4页
Chinese Journal of Endocrine Surgery
关键词
急性脑梗死
依达拉奉
氯吡格雷
自由基
血小板
Aacute cerebral infarction
Edaravone
Clopidogrel
Free radical
Platelet
作者简介
张建华，Email：wahdr@hotmail．com
