摘要
目的:研究佛甲草醇提物对大鼠佐剂性关节炎的治疗作用并探讨其对氧自由基的影响。方法:采用弗氏完全佐剂免疫诱导大鼠佐剂性关节炎动物模型;观察不同浓度佛甲草提取物对佐剂性关节炎(AA)大鼠的慢性足肿胀度、血清中一氧化氮(NO)含量及谷胱甘肽过氧化物酶(GSH-PX)活性的影响。结果:与模型组相比,高、低剂量的佛甲草醇提物均能抑制大鼠慢性足肿胀,降低大鼠的血清NO水平,并使GSH-Px的含量增加。结论:佛甲草醇提物对大鼠佐剂性关节炎有治疗作用,其作用可能与其恢复抗氧化物酶活性,提高自由基的清除能力有关。
Objective： To observe the therapeutic effect of Sedum lineare Thunb（ SLT） on adjuvant arthritis and its effects on antioxidation in mice. Method： By establishing rheumatoid arthritis rats model with injecting Freund complete adjuvant,observe the effect of the high and low dosage of SLT to the chronic paw swelling,nitric oxide（ NO） content and glutathione peroxidase（ GSH-Px） activity in serum. Result： Both SLT groups could reduce the swelling of the model rats,change the level of serum NO,which were lower than the model group,whereas the SLT groups increased the activity of serum GSH-Px. Conclusion： SLT had therapeutic action to rheumatoid arthritis rats,and the mechanism probably was that SLT could strengthen the activity of antioxidase,and scavenge oxygen-free radicals.
出处
《赣南医学院学报》
2014年第3期329-331,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
江西省卫生厅科技项目(NO.20141117)
作者简介
通讯作者：黄志华，生理学教授，硕士研究生导师，研究方向：中药药理。E-mail：18970786003@163．com
