摘要
目的观察大豆异黄酮胶囊治疗高原红细胞增多症(HAPC)的疗效。方法在海拔5000m以上高原,对临床确诊的38例HAPC患者给予大豆异黄酮胶囊口服,20mg/次,2次/d,连续服用3个月,观察治疗后患者症状改善情况。采用超声心动图检测治疗前后右室舒张末前后径(RVED)、右室前壁厚度(RVAW)、右室流出道内径(RVOT)、肺动脉主干内径(MPA)等,监测心率(HR)和血氧饱和度(SaO2)的变化,采血检测血红蛋白(Hb)与血细胞比容(Hct)的变化及血清超氧化物歧化酶(SOD)和丙二醛(MDA)含量,并进行6分钟步行距离实验(6MWT)。结果与治疗前比较,治疗后Hb、Hct明显降低,SaO2增高(P<0.01),HR变化无统计学意义(P>0.05),RVED、RVAW、RVOT、MPA降低(P<0.01),SOD增高,MDA降低(P<0.05或0.01),6MWT示肺功能改善明显。结论大豆异黄酮对HAPC及其引起的血流动力学改变具有明显的改变作用。
Objective To observe the therapeutic effect of soybean isoflavone on high altitude polycythemia （HAPC）. Methods At an area of above 5000m altitude, 38 patients clinically diagnosed as HAPC were orally administered soybean isoflavone capsule in 20mg/time, 2 times/d for three months. Before and after administration, the clinical manifestations of all the patients were observed, and ultrasonic cardiography was used to evaluate right ventricular end-diastolic dimension （RVED）, right ventricular anterior wall （RVAW）, right ventricular outflow tract （RVOT） and main pulmonary artery diameter （MPA）. Heart rate （HR）, arterial oxygen saturation （SaO2）, hemoglobin （Hb）, hematocrit （Hct）, superoxide dismutase （SOD） and malonaldehyde （MDA） were determined, and the six-minute walk test （6MWT） was performed. Results After treatment, Hb, Hct, RVED, RVAW, RVOT, MPA and MDA declined significantly （P〈0.01）, and SaO2 and SOD increased significantly （P〈0.01 or P〈0.05）, but the HR showed no change （P〉0.05） compared with that before treatment. The 6WMT showed the lung function was obviously improved. Conclusion Soybean isoflavone may possess the therapeutic effect on preventing and treating high altitude polycythemia.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2013年第12期1011-1014,共4页
Medical Journal of Chinese People's Liberation Army
基金
国家科技支撑计划项目(2009BAI85B02)
兰州军区"十一五"攻关项目(08G081)~~
作者简介
崔建华，研究员。主要从事高原疾病控制的研究
[通讯作者]孔佩艳，E-mail：peiyankong@aliyun．com
