摘要
目的:探讨长期氧疗(LTOT)对移居海拔5 000 m以上青年慢性高原病(CMS)预防作用。方法:对进驻海拔5 070 m、5 200 m和5 380 m的96例男性青年,在进入高原后每人每天持续鼻管吸氧(2 L/min)1 h(LTOT组),驻守1年根据国际CMS诊断标准进行CMS流行病学调查,采用超声诊断仪检测右室舒张末前后径(RVED)、右室前壁厚度(RVAW)、右室流出道(RVOT)、肺动脉主干内径(MPA)和左室后壁收缩末内径(LVSD),同时采血检测丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及一氧化氮合酶(NOS)和氧饱和度(SaO2)的含量,并与2008年驻守相同海拔高度1年的同一群体91例青年(未采用任何干预措施,对照组)作对照。结果:①CMS流行病学调查显示,LTOT组较对照组SaO2增高,有显著性差异(P<0.05);CMS患病率降低,有显著性差异(P<0.05)。②超声心动图结果显示,LTOT组较对照组RVAW、RVED、RVOT降低,有显著性差异(P<0.05,P<0.01),LVSD、MPA无统计学差异(P>0.05)。③生化指标结果显示,LTOT组较对照组SOD、NO、NOS增加,有显著性差异(P<0.05,P<0.01),MDA、ALT、AST、LDH降低,有显著性差异(P<0.05,P<0.01),γ-GT、CK无统计学差异(P>0.05)。结论:在高海拔地区LTOT能减轻脂质过氧化反应,改善缺氧造成的重要脏器损伤及保护线粒体氧化呼吸功能,对预防慢性高原病的发生有重要作用。
Objective： To explore the effect of prophylaxis on youth＇s chronic mountain sickness（CMS） who moved to an altitude of above 5 000 meters by long-term oxygen therapy（LTOT）. Methods： Ninety-six male youth stationed at 5 070 m, 5 200 m and 5 380 m took oxygen continuously by nasal cannula（LTOT group） every body per day. One year later, epidemiological survey were carried out according to the international CMS diagnostic criteria consist of examining right ventricle end-diastolic dimension （RVED）, right ventricular anterior wall （RVAW） ,right ventricular outflow tract （RVOT）, main pulmonary artery （ MPA）, left ventricular end systolic diameter （LVSD） by ultrasonic diagnostic apparatus, and blood test of alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, γ-glutamyl transpeptidase（ γ-GT）,creatine kinase（CK）, lactate dehydrogenase（LDH）, superoxide dismutase（SOD）, malondialdehyde （MDA）, nitric oxide（NO）, nltric-oxide synthase（NOS） blood oxygen saturation（SaO2）. Then, they were compared with 91 males in the same group stationed at the same altitude （without any interventions, control group）. Results： ①The epidemiological survey showed that, SaO2 were increased significantly （P 〈 0.05）and the prevalence rate of CMS were decreased compared with that of control group （ P 〈 0.05）. ②Echocardiography showed that SOD,NO, NOS were increased（ P 〈 0.05 or 0.01） and LVSD,MPA had no significant difference compared with that of control group （ P 〉 0.05）. ③Biochemical index showed that, SOD, NO, NOS were increased （ P 〈 0.05 or 0.01 ）, MDA, ALT, AST, LDH were decreased （ P 〈 0.05 or 0.01 ） and γ-GT,CK had no significant difference compared with that of the control group. Conclusion： At high altitude, LTOT can reduce lipid peroxidation, improve the important organ injuries caused by hypoxia and protect the mitochondria respiratory function and play an imporrant role on the prevention of chronic mountain sickness.
出处
《中国应用生理学杂志》
CAS
CSCD
2013年第5期391-394,共4页
Chinese Journal of Applied Physiology
基金
国家科技支撑计划项目(2009BAI85B02)
军队"十一五"攻关资助项目(08G081)
高原医学教育部重点实验室资助项目(2011JSGY05)
兰州军区基金课题(CWS10JA04)
关键词
高原
氧疗
慢性高原病
超声心动图
自由基代谢
血清酶
high altitude
long-term oxygen therapy
CMS
ultrasonic heartbeat graph
free radical metabolism
serum enzyme
作者简介
【通讯作者】Tel：0998-2731011；E-mail：wangfuling18@163．com
