摘要
目的:观察盐制杜仲的乙醇浸膏对去势大鼠骨密度及血清激素的影响。方法:采用雌性大鼠切除双侧卵巢建立骨质疏松症模型,随机分成假手术组、模型组、尼尔雌醇组、盐制杜仲提取物高、中、低剂量组(6,3,1.5 g·kg-1,ig)。手术后7 d开始给药,持续12周。检测各组腰椎和股骨的骨矿物质含量(BMC)和骨矿物质密度(BMD),血清雌二醇(E2)和胰岛素样生长因子1(IGF-I)的含量。结果:与假手术组比较,模型组大鼠的BMC和BMD明显下降,血清E2和IGF-I水平明显下降;盐制杜仲能增加去卵巢大鼠BMC和BMD,提高血清E2和IGF-I水平,与模型组相比有差异性(P<0.05)。结论:炮制能加强杜仲的抗骨质疏松作用,盐制杜仲通过上调血清E2水平,提高血清IGF-I含量而对去卵巢大鼠的骨质疏松症有预防或延缓发生的作用。
Objective：To observe the effects of salt-processing Eucommiae Cortex on BMD and serum hormone in rats after ovariectomy.Method：The model of postmenopausal osteoporosis was developed by ovariectomy,the rats were randomly divided into six groups,including sham operation group,model group,Nilestriol group,and salt-processing Eucommiae Cortex high,moderate,low-dose group（6,3,1.5 g·kg-1,ig） 7 days later,successive administration was carried out,lasted for 12 weeks.The lumbar spine and femoral bone BMC and BMD,serum E2and IGF-I content were assayed.Result：Compared with control group,BMC and BMD in model group rats decreased obviously,serum E2,IGF-I level decreased.Compared with model group,salt-processing Eucommiae Cortex could increase BMC and BMD,and serum E2,IGF-I level in rats after ovariectomy（P ＆lt; 0.05）.Conclusion：Processing can enhance the anti-osteoporosis effect of Duzhong,saltprocessing Eucommiae Cortex can prevent and delay osteoporosis in rats after ovariectomy by increasing serum E2,IGF-I level.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第17期255-257,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
中央高校基本科研业务费专项资金资助
SWJTU11BR068
关键词
骨质疏松
去势模型
盐制杜仲
骨密度
胰岛素样生长因子1
osteoporosis
ovariectomy model
salt-processing Eucommiae Cortex
bone mineral density
IGF-I.
作者简介
[通讯作者]李娜，讲师，从事中药化学与中药药理研究，E—mail：378719951@qq．com
