摘要
目的探讨全身振动对绝经后骨质疏松症患者细胞因子水平的影响。方法采用随机对照研究,70例入选的绝经后骨质疏松症志愿者随机分为振动组(n=35)和对照组(n=35)。两组受试者每日均服用钙尔奇D600mg。振动组:应用频率为30Hz的振动治疗仪,3次/周,10min/次,共12周振动干预;对照组仅服用相同剂量的钙尔奇D。观察两组患者干预前后腰椎骨密度(BMD)、疼痛程度和血清内IL-1β、TNF-α和IGF-1的变化。结果与干预前相比,振动组和对照组患者的腰椎BMD均有显著上升[(0.797±0.074)g/cm2vs.(0.734±0.071)g/cm2,(0.802±0.073)g/cm2vs.(0.740±0.064)g/cm2,均P<0.05],骨痛症状均有明显改善,但是振动组BMD的提高及骨痛的改善更为明显(与对照组相比,P<0.05);振动干预后患者血清内IL-1β和TNF-α显著降低[(15.9±4.4)ng/Lvs.(10.1±3.8)ng/L,(165.4±20.6)ng/Lvs.(82.5±18.6)ng/L,均P<0.05],IGF-1显著增高[(96.5±17.2)μg/Lvs.(178.3±22.5)μg/L,P<0.05];对照组实验前后三者均无显著变化。结论 30Hz全身振动具有防治绝经后骨质疏松症的作用,其机制可能与其下调IL-1β、TNF-α水平,上调IGF-1水平有关。
Objective To observe the effects of whole body vibration(WBV)on cytokine levels in postmenopausal women with osteoporosis.Methods In a randomized trial,70 postmenopausal women with osteoporosis were enrolled,and divided into WBV(n=35)and control(n=35)groups.Both groups were treated with calcium carbonate D 600 mg/qd.The patients in WBV group received 30 Hz WBV(10 min per time,3 times a week)for 12 weeks.The control group received calcium carbonate D only.Bone mineral density(BMD),pain scale and serum IL-1β,TNF-α and IGF-1 were evaluated.Results BMD were significantly increased and pain improved both in WBV and control groups after treatment,but the changes in WBV group were more noted than the control group.WBV significantly decreased IL-1β[(15.9±4.4)ng/L vs.(10.1±3.8)ng/L,P<0.05]and TNF-α levels[(165.4±20.6)ng/L vs.(82.5±18.6)ng/L,P<0.05]and increased the IGF-1 level [(96.5±17.2)μg/L vs.(178.3±22.5)μg/L,P<0.05],while there were no changes in the control group.Conclusions WBV could ameliorate the postmenopausal osteoporosis with a related mechanism of regulating IL-1β,TNF-α and IGF-1 levels.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第19期5931-5934,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
北京市朝阳区科委资助项目(SF1018)
