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溃疡性结肠炎发病机制中免疫因素的研究进展 被引量：110

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摘要 溃疡性结肠炎是一种常见的慢性肠道疾病,近年来发病呈上升趋势,而其发病机制目前尚不明确。目前认为与多种因素有关。环境因素作用于遗传易感者,在肠道菌丛的参与下,启动肠道免疫和非免疫系统,发生免疫反应和炎症,从而出现临床症状。其中免疫异常被认为是溃疡性结肠炎发病的重要因素,主要包括自身抗体、细胞免疫、细胞因子、环氧合酶与基质金属蛋白酶、氧自由基和一氧化氮等。本文综述了溃疡性结肠炎免疫发病机制中的各种影响因素。
作者 解春静 庄彦华 栾雨茏
机构地区 黑龙江省牡丹江医学院红旗医院消化科 解放军第
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第8期889-892,共4页 Chinese Journal of Cellular and Molecular Immunology
关键词 溃疡性结肠炎 发病机制 免疫因素 自身抗体 细胞免疫 细胞因子
分类号 R574.62 [医药卫生—消化系统] R392.11 [医药卫生—免疫学]
作者简介 解春静（1975-），女，黑龙江牡丹江人，副主任医师，医学硕士Tel：13804806291：E—mail：yangguang_8876@163．com。Corresponding author，解春静，E—mail：yangguang_8876@163．com
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参考文献31

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二级参考文献9

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共引文献4

同被引文献1215

引证文献110

二级引证文献1079

细胞与分子免疫学杂志
2013年 第8期

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