摘要
目的观察半量维替泊芬光动力疗法(Photodynamic Therapy,PDT)治疗慢性中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)的视力变化、黄斑区视网膜下积液吸收及脉络膜血管扩张的改善情况。方法对32例(38只眼)慢性CSC患者,行半量维替泊芬(3 mg/m2)光动力治疗,治疗后1周、1个月、3个月复查。随访期间进行最佳矫正视力、裂隙灯下间接眼底镜检查、光学相干断层扫描(OCT)检查,治疗后3个月时进行荧光素眼底血管造影(FFA)、吲哚菁绿血管造影(ICGA),观察治疗的有效性和安全性。结果术后OCT视网膜下积液均有不同程度的吸收,大多数病例FFA中显示荧光渗漏消失或渗漏减轻,ICGA显示扭曲扩张的脉络膜血管管径恢复正常或血管扩张减轻。随访期间32例均未见不良反应。结论半量维替泊芬PDT治疗慢性CSC短期内安全有效。
OBJECTIVE To evaluate the effects of photodynamic therapy（PDT） with half-dose verteporfin on the prognosis of visual acuity, the resolve of submacular fluid and the choroidal vessel dilatation for chronic central serous chorioretinopathy （CSC）. METHODS Thirty-two patients （38 eyes） received PDT with half-dose verteporfin （3mg/mZ）. For the evaluation of effect and safety, the best-corrected visual acuity （VA）, fundus examination by indirect ophthalmoscopy with slit-lamp, and OCT were documented at one week, one month and three months follow-ups, and fundus fluorescein angiography （FFA） and indocyanine green angiography （ICGA） were performed at the follow-up of three months. RESULTS The post-PDT OCT showed the submacular fluid of all patients was resolved in various degrees. The post-PDT FFA showed the fluorescein leak disappeared or improved, and ICGA showed the dilated and distorted ehoroidal vessels went back to normal diameter or improved. No adverse reaction was found in all patients during follow-up. CONCLUSIONS at least in short-term in the treatment of chronic CSC. PDT with half-dose verteporfin was effective and safe
出处
《中国中医眼科杂志》
2013年第2期133-135,共3页
China Journal of Chinese Ophthalmology
作者简介
通讯作者：潘秀红．E-mail：pxh_528@sohu．com
