摘要
目的观察麝香保心丸联合阿司匹林对稳定型心绞痛患者血脂联素(APN)、内皮素-1(ET-1)和一氧化氮(NO)的影响。方法将108例稳定型心绞痛患者随机分为观察组和对照组,每组54例。两组患者除治疗原发病、调脂、稳定斑块、对症等治疗外,对照组予阿司匹林片0.1g,1次/日口服。观察组予麝香保心丸45mg,3次/日口服,阿司匹林片0.1g,1次/日口服。疗程为12周。观察两组患者治疗前后APN、ET-1及NO的变化。结果观察组治疗后血APN、NO水平明显高于治疗前和对照组,血ET-1水平明显低于治疗前和对照组,差异有统计学意义(P<0.01)。结论麝香保心丸联合阿司匹林治疗,在抗动脉粥样硬化和保护内皮功能方面优于单纯使用阿司匹林。
Objective To observe the effect of Shexiang Baoxin pill（SBP） combined with aspirin on serum adiponectin（APN）,endothelin-1（ET-1） and nitric oxide（NO） in patients with stable angina pectoris.Methods One hundred and eight patients with stable angina pectoris were randomly divided into two groups：Control group（n=54） treated by aspirin,and observation group（n=54） treated with SBP and aspirin for 12 weeks.The levels of serum APN,ET-1 and NO were measured and compared.Results The levels of serum APN,NO in observation group were higher than that before treatment and control group.The serum ET-1 level in observation group was obviously lower than that before treatment and control group（P＆lt;0.01）.Conclusion SBP combined with aspirin could protect against atherosclerosis and endothelial function,which was better than aspirin alone for treatment of stable angina.
出处
《中西医结合心脑血管病杂志》
2013年第2期143-144,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
作者简介
邹慧兰，女，副主任医师
通讯作者
