摘要
目的探究丹红注射液联合益心汤治疗气虚血瘀型冠心病对患者心电图ST段改变、血清同型半胱氨酸(Hcy)、载脂蛋白a(Apo-a)、载脂蛋白b(Apo-b)水平及心血管事件的影响。方法随机选取2015年9月—2019年6月在该院心血管内科进行治疗的气虚血瘀型冠心病患者100例,按照随机数字表法随机分为治疗组与对照组两组,每组患者50例。对照组患者给予丹红注射液治疗,治疗组患者给予丹红注射液联合益心汤治疗,两组患者均连续治疗4周。比较两组患者的临床基本资料。对两组患者的临床疗效进行评价,观察治疗前后两组患者心电图ST段改变情况,测定两组患者血清Hcy、Apo-a、Apo-b水平变化。观察患者心梗、心衰、心室颤动等的发生情况。结果对照组与治疗组患者的总有效率分别为80.00%(40/50)、94.00%(47/50),治疗组明显高于对照组(P<0.05)。与治疗前对比,治疗后,两组患者ST段压低数值总和、ST段压低≥2.5 mm导联数及血清Hcy、Apo-a、Apo-b水平均明显降低,且治疗组降低更明显(P<0.01)。对照组与治疗组患者心血管事件总发生率分别为24.00%(12/50)、8.00%(4/50),治疗组明显低于对照组(P<0.05)。结论丹红注射液联合益心汤治疗气虚血瘀型冠心病,能够明显降低患者血清Hcy、Apo-a、Apo-b水平,降低心血管事件的发生率,具有显著的临床疗效。
Objective To explore the effect of Danhong Injection(丹红注射液)combined with Yixin Decoction(益心汤)on ST segment of ECG,serum homocysteine(Hcy),apolipoprotein a(Apo-a),apolipoprotein b(Apo-b)and cardiovascular events in patients with coronary heart disease of Qi deficiency and blood stasis type.Methods From September 2015 to June 2019,100 patients with coronary heart disease of Qi deficiency and blood stasis type were randomly selected to be treated in the cardiovascular department of our hospital.According to the random number table method,they were randomly divided into treatment group and control group,with 50 patients in each group.The patients in the control group were treated with Danhong Injection and those in the treatment group were treated with Danhong Injection and Yixin Decoction for 4 weeks.The basic clinical data of the two groups were compared.The clinical effect of the two groups was evaluated.The changes of ST segment of ECG before and after treatment were observed and the changes of serum levels of Hcy,Apo-a and apo-b in the two groups were measured.The occurrence of myocardial infarction,heart failure and ventricular fibrillation was observed.Results The total effective rate of the control group and the treatment group was 80.00%(40/50)and 94.00%(47/50),respectively,and the treatment group′rate was significantly higher than that of the control group(P<0.05).Compared with those before treatment,the sum of ST segment depression,the number of ST segment depression≥2.5 mm leads and the levels of Hcy,Apo-a and Apo-b in the two groups after treatment were significantly reduced,and the decrease in the treatment group was more significant(P<0.01).The total incidence of cardiovascular events was 24.00%(12/50)in the control group and 8.00%(4/50)in the treatment group.The incidence was in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Danhong Injection combined with Yixin Decoction can significantly reduce the levels of Hcy,apo-a and apo-b in patients with coronary heart disease of Qi deficiency and blood stasis type and reduce the incidence of cardiovascular events.It has significant clinical effect.
作者
尹贤哲
韩天雄
范俊飞
YIN Xianzhe;HAN Tianxiong;FAN Junfei(Shanghai 10th People's Hospital Attached to Tongji University,Shanghai 200072,China)
出处
《辽宁中医杂志》
CAS
2021年第8期161-164,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市进一步加快中医药事业发展三年行动计划(2018—2020年)[ZY(2018—2020)-CCCX-1003]
关键词
丹红注射液
益心汤
气虚血瘀型冠心病
Danhong Injection(丹红注射液)
Yixin Decoction(益心汤)
coronary heart disease of Qi deficiency and blood stasis type
作者简介
尹贤哲(1985-),女,湖南邵东人,主治医师,学士,研究方向:冠心病、心衰、脑梗死及其后遗症;通讯作者:范俊飞(1985-),女,上海人,主治医师,硕士,研究方向:中医治疗心脑血管疾病。
