摘要
采用溶剂注入法制备水杨酸壳聚糖/卵磷脂纳米粒。考察了粒子结构、形貌特征及表面电位等性能,并探讨了制备工艺对药物包封率的影响。确定最佳制备工艺为:卵磷脂质量浓度20 g/L、卵磷脂与壳聚糖及水杨酸与载体的质量比分别为3∶1和1∶6、水相pH=4。所制备的水杨酸壳聚糖/卵磷脂固体纳米粒子为球形粒子、表面电位+18.7 mV、包封率及载药量可分别达到55%和8.07%。
Salicylic acid-loaded lecithin/chitosan nanoparticles were prepared by solvent injection method.The structure,morphology as well as surface potential of the nanoparticles were investigated.The effects of preparation technology on drug entrapment efficiency were also studied by using the dialysis technique.The preparation process adapted to the formulation was as follows：the mass concentration of lecithin was 20 g/L,lecithin-chitosan and SA-carriers mass ratios were 3∶ 1 and 1∶ 6 respectively,and the pH of water phase reached 4.The Zeta potential of the optimized spherical nanoparticles was ＋18.7 mV with encapsulation efficiency and drug loading being 55% and 8.07% respectively.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2012年第10期972-975,984,共5页
Fine Chemicals
关键词
水杨酸
壳聚糖
卵磷脂
纳米粒
医药与日化原料
salicylic acid
lecithin
chitosan
nanoparticles
drug and cosmetic materials
作者简介
宋平（1989-），男，硕士研究生。
联系人：何秋星（1969-），男，副教授，博士，硕士生导师，E—mail：heqiuxing@126．com。
