摘要
目的介绍多糖微粒制剂的研究进展。方法综述了近年来国内外相关报道,介绍和评价多糖微粒制剂的制备方法、性能和药效等,指出多糖纳米制剂的研究前景。结果多糖微粒制剂有助于改善多糖药物稳定性差、生物利用度不高以及对某些细胞穿透能力不强等缺点,并使多糖药物获得抗肿瘤增效、靶向等作用。结论多糖新型微粒制剂为癌症治疗提供了新的研究途径,具有很大的发展前景。
OBJECTIVE To review the update of the study on polysaccharide micro-preparations. METHODS The review discussed the research of novel micro-preparations of polysaccharides in recent years at home and abroad,and the method of preparation, performance, effective function were also summarized. RESULTS The novel micro-preparation of polysaccharide can not only improve stability, bioavailability, and difficulty in penetration to some cells of polysaccharide,but also enhance the pharmacodynamic action and induce the targeting of polysaccharide drugs. CONCLUSION The novel micro-preparations of polysaccharides are promising, which can be used for effective cancer therapy.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2009年第8期620-623,共4页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省科技攻关重点项目(2006C23015)
关键词
多糖
药物转运系统
脂质体
纳米粒
微球
polysaccharide
drug delivery system
microsphere
liposome
nanoparticle
作者简介
李旎，女，硕士生
通信作者：高建青，男，副教授，硕士生导师Tel：（0571）88208437 E-mail：gaojianqing@zju．edu．cn
