蛋白酪氨酸磷酸酶(PTPs)及其抑制剂的研究进展被引量：1

Recent Progress in Research on Protein Tyrosine Phosphatase and its Inhibitors

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摘要蛋白质酪氨酸磷酸酶家族是细胞信号转导中的重要调节因子,参与多种细胞功能的调控,在调控细胞生命活动中起着重要作用。蛋白酪氨酸磷酸酶的生理功能与诸多人类疾病有密切关系,例如癌症、糖尿病和免疫紊乱等。蛋白酪氨酸磷酸酶已经成为治疗上述疾病的靶标。文章综述了近年来蛋白酪氨酸磷酸酶及其抑制剂的研究进展。 Protein tyrosine phosphatase （PTPs） family was an important cell signal transduction factor, which involved in many regulating cell functions and played an important role in the control of the action of cells. Physiological function of PTPs was related with human diseases such as cancer, diabetes and immune disorder. PTPs became a key pharmaceutical target in the treatment of diseases. The recent research developments in the study of PTPs were reviewed.

作者吴狄邓祥王坤黄小梅

机构地区四川文理学院化学与化学工程系

出处《广州化工》 CAS 2012年第9期11-12,37,共3页 GuangZhou Chemical Industry

基金四川省教育厅青年基金项目(10ZB105) 四川省教育厅重点项目(10ZA143) 四川省教育厅重点项目(11ZA169)

关键词蛋白酪氨酸磷酸酶信号转导靶标 protein tyrosine phosphatase （PTPs） signal transduetion target

分类号 O62 [理学—有机化学]

作者简介通讯作者：吴狄（1983-），男，硕士，助教，主要从事有机合成。

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