摘要
口腔黏膜下纤维化(OSF)可引起患者各种口腔功能障碍,并可恶变为口腔癌。OSF恶变的原因及过程涉及咀嚼槟榔、血管萎缩、组织缺氧、细胞周期改变、衰老、自噬、癌/抑癌基因、微小RNA改变等方面。研究OSF恶变原因及过程对OSF治疗、预防其恶变有重要意义。
Oral submucous fibrosis(OSF)can cause various oral dysfunctions in patients and can turn into oral cancer.The causes and processes of OSF malignant transformation involve betel nut chewing,vascular atrophy,tissue hypoxia,cell cycle changes,aging,autophagy,and changes in cancer/cancer suppressor genes and microRNAs.It is of great significance to study the causes and process of OSF malignant transformation for the treatment and prevention of OSF malignant transformation.
作者
周昌群
管晓燕
刘建国
岳超弈
廖成成
Zhou Changqun;Guan Xiaoyan;Liu Jianguo;Yue Chaoyi;Liao Chengcheng(Group 2,Department of Orthodontics,Affiliated Stomatological Hospital of Zunyi Medical University,Zunyi 563000,China;Key Laboratory of Oral Disease Research in General Colleges and Universities of Guizhou Province,Zunyi 563000,China;School of Medicine and Technology,Zunyi Medical University,Zunyi 563000,China)
出处
《国际肿瘤学杂志》
CAS
2022年第10期608-611,共4页
Journal of International Oncology
基金
国家重点研发计划(2016YFC1102800)
国家自然科学基金(82060205)
贵州省医用生物材料研发人才基地(黔人领发〔2018〕3号)
贵州省普通高等学校青年科技人才成长项目(黔教合KY字〔2021〕215)
关键词
口腔黏膜下纤维化
口腔肿瘤
恶变
Oral submucous fibrosis
Oral neoplasms
Malignant change
作者简介
通信作者:廖成成,Email:lcc_950330@163.com
