摘要
目的:研究辛苍鼻舒胶囊中细辛、川芎、苍耳子、辛夷所含挥发油的提取与包合工艺。方法:采用正交试验,以浸泡时间、加水量、提取时间为考察因素,以挥发油提取量为指标,考察提取工艺;以挥发油与β-环糊精比例、包合温度、包合时间为考察因素,以包合物收得率为指标,考察包合工艺。结果:挥发油最佳提取工艺为加10倍量水,浸泡1h,提取8h;最佳包合工艺为采用饱和水溶液法,挥发油与β-环糊精比例为1:6,在40℃下包合60min。结论:所选提取、包合工艺合理、可行。
OBJECTIVE： To investigate the extraction and inclusion technology of volatile oil from Radix Et Rhizoma Asari, Ligusticum chuanxiong, Xanthium sibiricum and Flos Mangnoliae in Xincang bishu capsules. METHODS： The extraction technology was optimized by orthogonal experiment with soaking time, amount of added water, extraction time as factors using the volume of volatile oil as index. The inclusion technology was investigated with ratio of volatile oil to β-cyclodextrin, inclusion temperature and inclusion time as factors using yield ratio of inclusion compound as index. RESULTS： The optimized extraction conditions were： 10-fold water, soaking for 1 h, extracting for 8 h. The optimal inclusion conditions were： applying the saturated aqueous solution method, the proportion of β-cyclodextrin to volatile oil was 6：1, lasting 60 min at 40 ℃. CONCLUSION： The optimum conditions for extraction and inclusion are reasonable and feasible.
出处
《中国药房》
CAS
CSCD
2012年第23期2137-2139,共3页
China Pharmacy
关键词
辛苍鼻舒胶囊
挥发油提取
Β-环糊精包合
工艺
正交试验
Xincang bishu capsules
Extraction of volatile oil
Inclusion with fl-cyclodextrin
technology
Orthogonal exper ment
作者简介
李罗清,主管中药师。研究方向:医院中药学。电话:0752-2189837。E-mail:13680876676@139.com;通讯作者:田素英,高级实验师。研究方向:中药鉴定与开发应用。E-mail:zsxptsy@126.com
