摘要
采用溶胶凝胶法制备了具有生物活性的SiO2/聚乙醇酸-乳酸共聚物(PLGA)组织工程支架材料。该方法选用廉价的硅溶胶作为硅源制备二氧化硅凝胶,简单易行,大大降低了成本。用模拟体液(SBF)溶液对含有SiO2的PLGA支架材料进行体外模拟浸泡实验。从电子探针照片上可以看到制得的含有SiO2的PLGA多孔支架材料有着良好的微孔性,可用作组织工程支架。支架材料在SBF溶液中浸泡72 h后:电子探针元素分析发现支架材料表面沉积物中有大量钙、磷等元素;XRD图谱在2θ=32°处出现的结晶峰,证实了支架表面碳酸羟基磷灰石的形成。研究表明,所制得的含有SiO2的PLGA多孔支架材料具备良好生物活性。
The sol-gel technology was adopted as a new method to prepare bioactive SiO2/ poly（lactic acid-co-glycolic acid）（PLGA） scaffolds for the first time.Cheap silica sols were used as the source of silica.This method was simple and convenient.After prepared,the SiO2/PLGA scaffolds were immersed in the simulated body fluid（SBF） solution and were evaluated by electron probe,X-ray diffraction（XRD）,differential scanning calorimetry（DSC）.The pictures of electron probe showed that there are many holes in SiO2/PLGA scaffolds.This means that SiO2/PLGA scaffolds can be used as tissue engineering scaffolds.After SiO2/PLGA scaffolds were immersed in the SBF solution for 72h,poorly-crystal apatite was formed on the surface of the scaffolds.That is proved by the sediment of a great deal of calcium and phosphorus appeared on the surface of the scaffolds in electron probe pictures and the apatite’s dispersion apex at 2θ=32° in XRD patterns.The results suggest that SiO2/PLGA scaffolds are bioactive and the method is feasible.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2011年第10期169-172,176,共5页
Polymer Materials Science & Engineering
基金
国家自然科学基金资助项目(50872068)
山东省优秀中青年科学基金(2007BSB02040)资助
作者简介
通讯联系人：葛建华，主要从事复合材料及生物材料研究，E-mail：gjhl00000@sohu．com
