摘要
本文在介绍流体动力学色谱中应用最广泛的水动力色谱基本原理、装置和分析方法的基础上,综述了水动力色谱在微粒制剂粒径测定及其分布估算方面的应用。该方法在快速测定纳米、微米尺度颗粒的粒径方面具有经济、便捷和无损伤等独特的优势,在微粒制剂粒径分布特征检测上具有良好的应用前景。
In the present paper,the basic principles,the device and the analytical method of the hydrodynamic chromatography（HDC） were summarized,which is most widely used in hydrokinetic chromatography.The application of the hydrodynamic chromatography in the determination of the particle size and size distribution of the particulate drug delivery system was also reviewed.The method can determine the particle size of nano-and micron-scale particulate drug delivery systems rapidly.And this method also has the advantages of economic,convenient and no damage to the samples.In summary,there will be a good prospect for the application of HDC in the determination of particle size distribution features of particulate drug delivery systems.
出处
《药学学报》
CAS
CSCD
北大核心
2011年第6期631-636,共6页
Acta Pharmaceutica Sinica
关键词
水动力色谱
微粒制剂
粒径
粒径分布
hydrodynamic chromatography
particulate drug delivery system
particle size
particle size distribution
作者简介
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