摘要
目的 探讨一种简便易行的检测急性白血病残留病变的方法。方法 对 2 7例急性白血病化疗后骨髓涂片首次完全缓解 (CR)时的骨髓切片进行同步观察 ,计数单位面积内原始细胞簇及原始细胞总数。原始细胞簇≥ 3 / mm2定为切片未完全缓解。结果 2 7例中 13例未达切片 CR,占 4 8%。切片中原始细胞总数与簇数呈显著正相关 ,r值 0 .918。切片缓解组完全缓解期明显长于未缓解组。对骨髓切片未 CR者继续行诱导化疗至原始细胞簇 <3 / mm2 ,再行巩固治疗及强化治疗 ,可明显延长 CR期。结论 骨髓切片内原始细胞簇计数检测急性白血病残留病变简便可靠 ,可真实反映诱导化疗后的骨髓缓解状况 ,弥补涂片结果之不足。
Objective To find a simple and pratical method for the detection of residual disease in acute leukemia(AL).Methods We studied 27 cases of AL by observing their bone marrow(BM) biopsy sections and simultaneously,their BM smears from which the first complete remission(CR) were determined after chemotherapy.The blast clusters and blast total number in per square minimetaer BM tissue were calculated.It was defined as unremissioned if the blast clusters were≥3/mm 2. Results 13 of 27(48%) cases were unremissioned on biopsy section when smears showed CR. Remrkable positive correlation was found between the blast clusters and the whole blast cell in biopsy sections.Long term of remission were obtained in those patients with CR both on smears and sections.As for those cases showing CR only on smears, the key to acquire continuous CR is going on with inducer chemotherapy till the blast clusters <3/mm 2. Conclusion The blast cluster calculation in BM biopsy section is of specific value on determining about BM remission and clinical prognosis because of its more real reflection about the situation of BM tissue after chemotherapy.
出处
《白血病》
1999年第5期271-273,共3页
关键词
骨髓活检切片
原始细胞簇
急性
白血病
残留病变
Bone marrow biopsy section Blast cluster acute leukemia Residual disease
