摘要
[目的]探讨星形细胞瘤术后放疗的疗效及预后影响因素。[方法]对66例经病理确诊的星形细胞瘤采用6MVX线进行术后放疗,常规分割,照射剂量(40～60)Gy/(20～30)F,4W～6W,分析影响预后的因素,应用Kaplan-Meier计算生存率,应用Log-rank进行预后的单因素分析,对单因素分析中P<0.05者进行Cox多因素回归分析。[结果]66例星形细胞瘤患者术后1、3、5年的生存率分别为79.7%、66.1%、52.4%,单因素及多因素分析均显示对术后生存率有影响的因素有年龄、手术切除方式、病理分级及靶区照射剂量。[结论]提高星形细胞瘤的生存率,应在不加重颅脑损伤的前提下尽可能肉眼全切肿瘤,术后尽早开始放疗,靶区剂量尽量达到(50～60)Gy,对于残留病变可采用三维立体适形放疗或调强放疗进行推量放疗以提高肿瘤局部控制率。
[Purpose ]To evaluate the effects of postoperative radiotherapy and the prognostic factors of astrocytomas. [Methods] Sixty-six patients with astrocytomas pathologically proved received postoperative radiotherapy. The dosage of target ranged from 40Gy to 60Gy （20F-30F. 4W-6W） with conventional fraction. The survival rate was ealculated by Kaplan-Meier methods and prognosis faeto,＇s were evaluated by Log-rank single variate analysis. Cox model multivariate analysis was used for those of P〈0.05 in single variate analysis. [Results] The 1-, 3- and 5-year survival rates were 79.7%, 66.1%, 52.4% respectively. Lnivarlate and multivariate analysis all revealed that age, surgical modalitv, pathological grade and dosage of target were influencing prognosis factors, [Conclusion] The survival rate is expected to be improved by total tumor reseeted, radiation as early as possible and target radio-dosage reached 50Gy-60Gy. For the residual lesion, 3-dimensional eonformal radiation therapy or intensity modulated radiation therapy should be used to improve the local control rate.
出处
《肿瘤学杂志》
CAS
2005年第6期438-440,共3页
Journal of Chinese Oncology
关键词
星形细胞瘤
放射疗法
治疗结果
影响因子
astrocytomas
radiotherapy
treatment outeome
influeneing factor
