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动物隐睾模型与不育研究进展 被引量:7

Study Progress of Cryptorchidism in Experimental Animal Models and Infertility
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摘要 隐睾症是一种最常见的泌尿系统疾病,是男性不育症的主要原因之一,且易引起睾丸恶变,甚至导致心理创伤。有关隐睾导致不育发病机制的研究在临床上不易做到,需通过动物隐睾模型解决。目前的动物隐睾模型有机械模型、激素诱导模型和转基因模型。研究发现隐睾导致的不育与隐睾睾丸的温度变化、附睾及睾丸的发育异常、激素因素、抗氧化酶活性降低及与凋亡有关基因的改变等有关,它们通过多种途径引起睾丸生殖细胞凋亡增加及抗精子抗体的产生,导致生精能力降低。隐睾手术年龄尽量要早,以便最大限度降低不育率。
作者 宋翠萍
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2009年第23期1790-1792,共3页 Journal of Applied Clinical Pediatrics
作者简介 宋翠萍,女,主任医师,教授,硕士学位,硕士生导师,《医学信息:内·外科版》《新乡医学院学报》编委,承担省部级课题4项,获科技成果奖2项,发表论文30余篇,研究方向为小儿外科疾病。
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