摘要
目的:研究黄芩苷-β-CD包合物的制备方法及其胶囊体外溶出度的测定。方法:用正交试验优选黄芩苷-β-CD包合物的最佳制备条件,采用饱和水溶液法制备包合物;并分别将黄芩苷-β-CD包合物和黄芩苷与β-CD物理混合物制成胶囊,以蒸馏水为溶出介质,采用桨法测定体外溶出度,比较黄芩苷-β-CD包合物胶囊与黄芩苷和β-CD物理混合物胶囊的溶出速度和溶出量。结果:黄芩苷与β-CD的最佳包合条件为:黄芩苷与β-CD的比例为1:2.5,包合时间为1.5h,包合温度为65℃;黄芩苷-β-CD包合物胶囊的体外累积溶出度大于黄芩苷与β-CD物理混合物胶囊。结论:黄芩苷-β-CD包合物制备工艺简单易行,包合物胶囊水溶性好,体外溶出快。
Objective： To study the preparation process for β-CD inclusion compound of baicalin and the dissolution rate of the baicalin-β-CD inclusion compound capsules. Methods： The optimized conditions of preparation were determined by orthogonal experiment design. The baicalin-β-CD was prepared by saturated water solution method. Used distilled water as dissolvent, the dissolution rate and the dissolution amount of baicalin from the inclusion compound capsules and the physical mixture capsules were determined and compared by the paddle method. Results： The optimized preparation conditions of baicalin-β-cyclodextrin are those that the ratio of baicalin and β-CD is 1 ： 2.5, the inclusion temperature is 65 ℃ and the stirring time is 1.5 h. The accumulated dissolution of baicalin-β-CD capsule is faster than that of the physical mixture capsule. Conclusion： The preparation process of baicalin-β-CD inclusion compound is available. The dissolution ofbaicalin from the inclusion compound is significantly increased.
出处
《中国药物应用与监测》
CAS
2009年第5期274-276,共3页
Chinese Journal of Drug Application and Monitoring
作者简介
【作者简介】贾金萍，女，硕士研究生，讲师，研究方向：中药制剂与中药质量标准研究。E—mail：jiajp@sxu．edu．cn
通讯作者：秦雪梅，女，教授，硕士研究生导师，研究方向：生物活性成分及中药质量控制研究。E—mail：qinxm@sxu．edu．cn
