摘要
目的:制备葛根素β-环糊精包合物,研究葛根素包合物渗透泵片的制备工艺和体外释药行为。方法:应用饱和水溶液法制备葛根素β-环糊精包合物,利用释药速率与衣膜组分之间的关系预测并设计正交实验优化处方。结果:饱和水溶液法制备包合物包封率为95.35%±1.15%,优化处方聚乙二醇(PEG)和邻苯二甲酸二丁酯(DBP)的用量分别为醋酸纤维素(CA)用量的5%和20%,膜增重量为片芯的6%。结论:正交实验设计并优化葛根素包合物渗透泵片处方的是一种可行的方法,其释放规律符合控释制剂要求。
Objective： To prepare the compound of puerarin with β-cyclodextrin, and study the preparation and drug release of osmotic pump tablet. Methods： The puerarin-β-CD inclusion compound was prepared with the method of saturation aqueous solution. Orthogonal test was designed to achieve the relationship between the release rate and composition of semi-permeable membrane. Results： The entrapment efficiency of puerarin-β-CD inclusion compound was 95.35% -1.15% by the method of saturation aqueous solution; the optimum formulation was as follows, the dosage of PEG and DBP were 5% and 20% to CA, the increasing weight of membrane was 6% to the tablet. Conclusions： It is a viable method in optimizing puerarin-β-CD prescription by orthogonal test. The release rule is conform to requirements of controlled release dosage form.
出处
《儿科药学杂志》
CAS
2014年第3期53-56,共4页
Journal of Pediatric Pharmacy
关键词
葛根素
Β-环糊精
包含物
渗透泵
正交实验
影响因素
Puerarin
β-cyclodextrin
Clathrate
Osmotic pump
Orthogonal test
Influencing factor
作者简介
作者简介：周佳敏（1982．07-），女，硕士，讲师，主要从事药剂学研究，E—mail：jasmine78118@163．com。
