摘要
目的:探讨荞麦多糖对小鼠睡眠功能和自发活动的影响。方法:①小鼠腹腔注射荞麦多糖,15min后放入吊笼中,稳定3min后记录用药后15s内小鼠活动波形。②腹腔注射荞麦多糖,15min后,腹腔注射阈上剂量的戊巴比妥钠,观察小鼠翻正反射消失时间。③腹腔注射荞麦多糖,15min后,腹腔注射阈下剂量的戊巴比妥钠,观察小鼠翻正反射消失时间。结果:①荞麦多糖能非常显著抑制小鼠自发活动。②荞麦多糖能显著加速阈上剂量戊巴比妥钠的入睡时间和延长戊巴比妥钠的睡眠时间。③荞麦多糖能显著加速阈下剂量戊巴比妥钠的入睡时间和延长戊巴比妥钠的睡眠时间,比较差异有非常显著性。与戊巴比妥钠有协同的中枢抑制作用。结论:荞麦多糖具有明显的延长昆明种小鼠睡眠时间和抑制小鼠自发性活动。
Objective ： To study the sleep effect and the spontaneous motion of Esculentum polysaccharide in mice. Methods ： （1）The mice were given Esculentum polysaecharide, 1Stain later, they were put in the slinged hutch and let stable for 3 min. Then to observe the action waves of the mice for 15s after being given the drug. （2）The mice were given Esculentum polysaccharide, Igmin later, they were given sodium pentobarbital in suprathreshold dose. To observe the latent period of the vanisher of the rignting reflex in the mice. （3）The mice were given, 15min later,they were given sodium pentobarbital in subthreshold dose. To observe the latent period of the vanisher of the rignting reflex in the mice. Results ：（1）Esculentum polysaeehafide could remarkably inhibit spontaneous motion such as big and middle waves. （2）Eseulentum polysaeeharide could obviously reduce the latent period of falling asleep and prolong the sleep time induce by sodium pentobarbital in suprethreshold dose. It shows very. reliable efficacy. （3）Esculentum polysaeeharide could obviously reduce the latent period of falling asleep and prolong the sleep time induce by sodium pentobarbital in subthreshold dose. So Esculentum polysaccharide could inhibit the central nervous system with sodium pentobarbital together. Condusion：Eseulentum polysaccharide shows remarkably inhibited central nervous system.
出处
《赣南医学院学报》
2009年第1期5-6,共2页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
荞麦多糖
戊巴比妥
睡眠
Esculentum Polysaccharide
pentobarbital sodium
sleep
