摘要
应用聚合酶链反应检测孕妇尖锐湿疣（ＣＡ）组织、无ＣＡ孕妇宫颈分泌物、外周血及羊水、新生儿咽分泌物、脐血中人乳头瘤病毒（ＨＰＶ）感染及母婴传播。结果表明：ＣＡ组织中ＨＰＶＤＮＡ阳性率为９０．３２％，以ＨＰＶ６／１１型为主；无ＣＡ孕妇宫颈分泌物中ＨＰＶＤＮＡ阳性率为３５．７１％，以ＨＰＶ１６／１８型为主；孕妇血中ＨＰＶＤＮＡ阳性率为５７．６９％；母婴间经产道垂直传播率为４４．４４％，血性经胎盘传播传播率为６０％。说明ＨＰＶ不仅存在于ＣＡ组织中，还存在于无ＣＡ孕妇生殖道及外周血中，母婴间传播途径除产道外。
To study the human papillomavirus (HPV) infection during pregnancy and transmission of virus to fetus, samples such as, cervical secretion, peripheral blood, amniotic fluid, neonatal umbilical blood from 96 women with normal pregnancy were screened for HPV DNA by polymerase chain reaction (PCR), and HPV DNA in condyloma acuminata tissues, amniotic fluid of 31 pregnant women were detected by PCR as well. The results showed HPV DNA positive rate of condyloma acuminata tissues was 92.32%, of cervical secretion in normal pregnant group, was 35.71%, of peripheral blood was 57.69%. The HPV DNA maternalfetus transmission rate was 44.44%, the transmission rate via placenta was 60%. It is concluded that HPV DNA can be found not only in condyloma acuminata tissues, but also in genital tract, peripheral blood of pregnant women, Besides the transmission route of genital tract, there is also the bloodplacenta route.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1997年第4期369-371,共3页
Chinese Journal of Experimental and Clinical Virology
基金
国家八五科技攻关基金
关键词
妊娠
人乳头瘤状病毒
感染
聚合酶链反应
Pregnancy Human papillomavirus Infection Polymerase chain reaction
