摘要
近年来研究发现宫内感染是围生期人乳头瘤病毒(HPV)母婴传播途径之一,以往人们认为HPV是通过胎儿与产道接触而传播的,目前研究发现非经阴道分娩的新生儿仍会感染HPV,由此提出HPV宫内感染的假设。后羊水中检测出HPV DNA进一步证实宫内感染的存在。目前HPV宫内感染的机制主要有血-胎盘途径和上行感染途径,具体机制尚不十分清楚,现应用的羊水HPV检测方法以聚合酶链反应和核酸杂交为基础。HPV感染可能造成不良妊娠结局,并影响婴儿健康。剖宫产能降低新生儿HPV感染率,但是不能有效阻止HPV传播,因此HPV感染不作为剖宫产指征。
In recent years,it is found that intrauterine infection is one of human papilloma virus(HPV) mother-to-fetus transmission in perinatal period.In the past,people thought the HPV is spread by contact with the birth canal.However,it′s found that the newborns would be infected with HPV by the non-vaginal delivery,thus it is put forward the hypothesis of HPV intrauterine infection.HPV DNA later detected in amniotic fluid confirms the possibility of intrauterine infection.At present,main mechanisms of HPV intrauterine infection are blood-placenta and ascending infection,while the specific mechanism has not been very clear.Now the application of amniotic fluid HPV detection method is based on polymerase chain reaction and nucleic acid hybridization.HPV infection may cause adverse pregnancy outcomes and can affect the health of the baby.Cesarean section can reduce the infection rate of HPV in newborns,but it cannot effectively prevent the transmi- ssion of HPV,so HPV infection is not an indication of cesarean section.
作者
李桐
宋金维
王建东
LI Tong;SONG Jinwei;WANG Jiandong(Department of Gynecologic Oncology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100010,China;Department of Gynecology and Obstetrics,Xicheng Maternal and Child Health Hospital,Beijing 100054,China)
出处
《医学综述》
2019年第4期779-783,共5页
Medical Recapitulate
基金
北京市科技计划课题(Z171100000417027)
关键词
人乳头瘤病毒
羊水
宫内感染
母婴传播
Human papilloma virus
Amniotic fluid
Intrauterine infection
Mother-to-fetus transmission
作者简介
通信作者:王建东,E-mail:wangjiandongxy@hotmail.com.
