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难溶性药物口服固体制剂的溶出度测定法和体内外相关性的研究进展 被引量:10

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摘要 综述近年中外文献中有关难溶性药物体外溶出度测定的试验方法、实验条件的选择和影响因素,以及体内外相关性的评价方法。溶出介质的种类、pH值、离子强度、增溶剂和表面活性剂和溶出度仪等均可影响体外溶出度的测定结果。应根据药物的物理化学性质,选择尽可能接近体内状态的方法,可得到更好的体内外相关性。
作者 唐素芳
出处 《天津药学》 2007年第5期58-61,共4页 Tianjin Pharmacy
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参考文献24

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