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TNF-α和IL-6在慢性心力衰竭中的变化及意义 被引量:22

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摘要 目的观察肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)在慢性心力衰竭(CHF)患者中的变化及其临床意义。方法用放免法测定49例基础疾病为缺血性心脏病、扩张型心肌病及高血压性心脏病的CHF患者和30例健康体查者的血清TNF-α和IL-6浓度,并进行比较分析。结果CHF患者血清TNF-α和IL-6水平明显高于正常对照组(P<0.01),并与左室射血分数(LVEF)呈显著负相关(P<0.01)。且心衰程度越重,TNF-α和IL-6升高越明显。结论CHF时血清TNF-α和IL-6浓度明显升高,并与CHF严重程度相关。TNF-α和IL-6可作为CHF患者临床评价的参考指标。
作者 陈双庆 杨震
出处 《江苏医药》 CAS CSCD 北大核心 2007年第10期1032-1033,共2页 Jiangsu Medical Journal
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