摘要
川芎嗪(Ligustrazine)是从中药川芎中提取的一种活性生物碱单体,随着对川芎嗪研究的不断深入,其临床应用范围亦日趋广泛,尤其对心血管疾病有显著的疗效。川芎嗪化学结构为四甲基吡嗪,其四个甲基被不同的功能基团替代后可产生不同效应,研究发现川芎嗪对心血管系统的作用有多种不同的作用途径和作用机制。本文仅介绍川芎嗪对心血管系统作用的研究进展。
Ligustrazine is an active alkaloidal monomer which is extracted from the Chinese traditional herb Chuanxiong （Ligusticum chuanxiong Hort. ）. With the in-depth research of Ligustrazine, its clinical use is widen day by day, especially its remarkable efficiency to the Cardiovascular Disease. The chemical structure of Ligustrazine is tetramethyl pyrazine, its four methyl can show different efficiency, when they are replaced by different functional units. It is found that the effect of Ligustrazine in the cardiovascular system has different ways and mechanisms of action. The pharmacological development of Ligustrazine in the cardiovascular system is reviewed.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2007年第5期484-487,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
川芎嗪
缺血再灌注损伤
心肌保护
Ligustrazine
ischemia-reperfusion injury
myocardial protection
作者简介
姜宏，女，博士研究生，讲师，研究方向：心肌干细胞的实验研究。Tel：025-85811629 E-mail：gingerjh@126．com
施广飞，通讯作者，男，主任医师，博士研究生导师，研究方向：心肌干细胞的实验研究。Tel：025-83304616 E-mail：yuhonson@hotmail．com
