摘要
目的研究糖肝康胶囊改善糖尿病大鼠的肝脏损害的作用。方法健康Wistar大鼠,尾静脉注射新鲜配制的链脲佐菌素溶液,同时给予高热量饲料,8周后,取血糖≥11.1mmol,并具有血脂紊乱的大鼠确定为糖尿病模型大鼠;实验时取糖尿病模型大鼠随机分为5组糖尿病模型组;糖肝康低、中、高剂量组;二甲双胍加肝泰乐对照组,每组10只。以等效剂量计算,口服灌胃给药,每日1次。给药第6周以及12周末断尾取血测各组血糖、血脂;上述动物给药12周后腹主动脉取血后处死,取肝脏称重,计算肝脏系数、测肝脏总胆固醇(TC)含量、测肝脏脂质过氧化物(LPO)含量及ALT、AST。另取大鼠观察糖肝康胶囊对大鼠四氯化碳慢性肝损伤的预防作用。结果糖肝康对糖尿病模型动物的高血糖、血脂紊乱有良好的治疗作用;对糖尿病性脂肪肝病理改变有良好防治作用;并且随着药物剂量的增加和用药时间的延长,其作用逐渐增强,其中糖肝康大剂量组的作用优于对照组,有显著性差异(P<0.01或P<0.05)。结论糖肝康胶囊对糖尿病大鼠肝损伤有良好的防治作用,可用于防治糖尿病性肝损伤。
Objective To study the effect of Tanggankang capsule treating liver trauma of diabetic mice. Methods Healthy Wistar rats are used in this trial. STZ are injected into the mice＇ s trail vein and they are fed with feed stuff with high quantity of heat. Eight weeks later, rats with blood sugar≥ 11.1 mmol and disturbance of lipid metabolism are selected as diabetic model. 50 rats were randomly divided into five groups：low, moderate and high dosage groups;Mefformin Hydrochloride and Glucurolactone control group. Every rat is given equal dosage by mouth once a day. After 6 weeks and 12 weeks, measure the blood sugar and lipid. At the 12th weeks, rats are sacrificed to weigh the liver and compute the liver coefficient and measure TC, LPO, ALT and AST. Results Tanggankang capsule has good therapeutic effect on treating hyperglycemia and disturbance of lipid metabolism for diabetic model; Tanggankang capsule can effectively prevent from the pathological change of diabetic fatty liver;what＇ s more, the more dosage and longer duration of drug, the stronger effect will appear,and the effect of large dosage is better than that of control group,thus the difference is remarkable （P 〈0.01or P 〈0.05）. Conclusion Tanggankang capsule can effectively prevent and treat the pathological changes and liver trauma of mice diabetic fat - liver.
出处
《医学研究杂志》
2007年第2期108-110,共3页
Journal of Medical Research
关键词
糖尿病
肝损伤
糖肝康胶囊
Diabetes
Hepatic Injury
Tanggankang capsule
