摘要
目的 :观察白芍总苷 (TGP)与当归提取物 (EAS)合用的抗肝炎作用。方法 :分别采用D 半乳糖胺 (D GL)和四氯化碳 (CCl4 )诱导小鼠发生实验性急性肝损伤。结果 :两药合用可对抗D GL和CCl4 所致血清中谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、碱性磷酸酶 (ALP)升高及还原型谷胱甘肽 (GSH)降低 ,减轻D GL所致肝脏病变程度 ,其中以 2 0 0mg/kg白芍总苷和相当于生 药15 3.4 g /kg当归提取物合用、给药 7d预防效果最佳。结论
Objective:To study the protective effects of total glucosides of paeony (TGP) and extract from Angelica sinensis (EAS) on experimental hepatitis. Method: Mouse acute liver injury model was induced by D galactosamine (D GL)or carbon tetrachloride(CCl 4).Result:The decrease of ALT, AST, ALP, and the increase of GSH in serum,which were induced by D GL or CCl 4,could be antagonised by TGP and EAS, the hepato cellular degeneration and necrosis induced by D GL could also be diminished. The optimal dosage is TGP(200 mg·kg 1 /d, 7 d, ig) plus EAS (153.4 g·kg 1 /d,7 d, ig). Conclusion: Pre treatment with TGP and EAS moderately prevents the liver damage induced by D GL or CCl 4.
出处
《安徽中医学院学报》
CAS
2002年第3期44-47,共4页
Journal of Anhui Traditional Chinese Medical College
关键词
白芍总苷
当归提取物
当归
白芍
D-半乳糖胺
四氯化碳
实验性肝炎
Total glucosides of paeony
Extract from Angelica Sinensis
D galactosamine
Carbon tetrachloride
Experimental hepatitis
