摘要
目的对青风藤（Sinomenium auctum（Thunb．）Rehd．et Wils．）化学成分进行分离、鉴定。方法适量干燥青藤茎用10倍量体积分数为70％的乙醇水溶液提取，减压回收乙醇，所得干浸膏研成细粉后，分别用环己烷、氯仿、甲醇超声溶取；采用ODS中低压柱色谱、制备型HPLC方法进行分离，并通过^1H-NMR、^13C-NMR、ES-MS等谱学技术对化合物进行结构鉴定。结果分离得到5个化合物，分别鉴定为穆坪马兜铃酰胺（N-trans-feruloyl tyramine, 1）、syringaresinol mono-β-D-glucoside（2）、1，2，4／3，5-cyclohexanepentol（3）、3-methoxy-6-hydroxy-17-methylrnorphinane（4）、青藤碱（sinomenine ，5）。结论化合物1～4为首次从防己属中分离得到。
Objective To study the chemical constituents of Sinomenium acutum. Methods The dried stems of Sinomenium acutum were extracted with 70 % ethanol and the solvent was removed by rotary evaporation to give an extract. The extract was dissolved in water, and partitioned with cyclohexane, chloroform and methanol, respectively. The constituents were isolated by the silica gel, ODS column chromatography and preparative HPLC, and their structures were confirmed by physico-chemical characters and spectroscopic analysis. Results Five compounds were obtained and identified as N-trans-feruloyl tyramine （1）, syringaresinol--mono-β-D-glucoside （2）, 1, 2, 4/3, 5-cyclohexanepentol （3）, 3-methoxy-6-hydroxy-17- methyl--morphinane （4）, sinomenine （ 5 ）. Conclusions Among these compounds, 1-4 were isolated from Sinomenium genus for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2007年第2期79-81,共3页
Journal of Shenyang Pharmaceutical University
关键词
青风藤
防己属
化学成分
Sinomenium acutum （Thunb.）Rehd. et Wils.
Sinomenium
chemical constituent
作者简介
宋永彬（1981-），男（汉族），黑龙江林口人，硕士研究生，E-mail：1981@sina.com；
邱峰（1967-），男（汉族），辽宁瓦房店人，教授，博士，主要从事中药体内代谢及天然药物活性成分研究，Tel．024-23993994．E-mail：fengqiu2000@tom．com.
