摘要
比较了17种树脂对β-环糊精单甲苯磺酰化产物的吸附特性,确定了大孔弱极性吸附树脂HZ-841对单取代物具有较高的吸附选择性和良好的脱附性能。测定了单取代物在树脂HZ-841上的吸附等温线、吸附动力学曲线和吸附速率曲线。考察了单取代物的动态吸附性能及解吸,给出了穿透曲线和洗脱曲线。结果表明,其吸附等温线符合Langmu ir方程,且均为优惠型吸附;吸附速率曲线符合二级Lagergren方程,5 h内基本达到吸附平衡;当树脂床层为80 mL、柱高40 cm时,质量浓度为4.8 g/L的混合样品溶液以2.5 mL/m in的流速进样,环糊精的穿透体积为200 mL,单取代物的穿透体积为1 130 mL。用90℃的700 mL热水可基本完全洗脱,环糊精和单取代物的洗脱率分别为98.1%和94.9%。
Seventeen resins were selected to compare their performances in adsorbing and desorbing monosubstituent in the mixture. Experimental results showed that HZ-841 resin possessed higher selectivity and desorption capacity. The adsorption characteristic of monosubstituent on HZ-841 resin was determined. The adsorption isotherms, kinetic curves, breakthrough curves and elution curves were determined. The adsorption isotherms were Langmuir type. The adsorption kinetic curve could be preferably described by the second-order Lagergren equation, and the adsorption equilibrium was achieved in about 5 h. On a column of φ 16 mm ×400 mm, the breakthrough volume of CD was 200 mL when the mixture concentration was 4.8 g/L, the flow rate was 2.5 mL/min, while that of monosubstituent was 1 130 mL. The adsorbate was completely eluted with 700 mL of hot （90℃ ） water, and the desorption rates were 98. 1% and 94.9% for/β-cyclodextrin and monosubstituent, respectively.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第8期821-825,共5页
Chinese Journal of Applied Chemistry
基金
教育部高等学校博士学科点专项科研基金项目(20040335045)
关键词
对甲苯磺酰-β-环糊精
树脂
吸附
分离
Mono-deoxy- （p-tolysulfonyl） -β-cyclodextrin, resin, adsorption, separation
作者简介
通讯联系人：周婕，女，1978年生，博士；E-mail：jie_0822@sina．com；研究方向：手性药物和天然药物的分离和制备
