摘要
目的：研究绿茎槲寄生的活性化学成分。方法：对绿茎槲寄生的乙醇提取物的有效部位，即醋酸乙酯溶解部分中主要化学成分进行分离鉴定，并经体外活性筛选，寻找促PC12细胞分化的活性物质。结果：获得了5个主要化学成分，即北美圣草素（1），5，7-二羟基-3′，4′-二甲氧基-二氢黄酮（2），齐墩果酸（3），5，7-二羟基色原酮（4），高北美圣草素（5）。经活性筛选试验发现，化合物高北美圣草素（5）具有促PC12细胞分化作用。结论：成分1-5均为首次从该植物中分离得到，并找到了活性单体成分高北美圣草素。
Objective. To investigate chemical constituents of the stem of Viscum nudum and their bioacyivity. Method： The major chemical constituents were isolated from the AcOEt-solved part of ethanol-extract of the plant by column chromatography and the active screenhag test in vitro were taken out for looking for compounds to acccelerate PC12 cell differentiation. Result： 5 compounds were identified as eriodictyol （1）, 5, 7-dihydroxy-3′, 4′-dimethoxy flavanone （2）, oleanolie （3）, 5, 7-dihydroxychromone （4） and homefiodietyol （5） by spectral evidences, in which homeriodictyol （5） had acceleration differentiation to PC12 cell. Conclusion： All compounds were obtained from this plant for the first time, and bioaetive constituent was observed in the AeOEt-solved part.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2006年第16期1340-1342,共3页
China Journal of Chinese Materia Medica
基金
科技部重大基础研究前期研究项目(2004CCA038-00)
贵州省优秀科技人才培养项目[黔科合人字(2002)0205号]
作者简介
[通讯作者]杨小生，Tel：（0851）3805459，E-mail：yang-xiaosheng@yahoo．com．cn
