摘要
目的:探讨肥大细胞和P物质在扁平苔藓发病中的作用。方法:采用组织化学和免疫组化的染色方法,检测扁平苔藓皮损中未脱颗粒的肥大细胞数和P物质的表达情况。结果:甲苯胺蓝特殊染色发现,扁平苔藓皮损中未脱颗粒的肥大细胞数(3.56±1.52)明显低于正常对照组(5.22±1.28),其差异具有统计学意义(P<0.01);免疫组化染色发现,扁平苔藓皮损中P物质的表达强度明显高于正常对照组,其差异具有统计学意义(P<0.01);采用Spearman等级相关分析,二者呈一定的负相关(rs=-0.397,P<0.05)。结论:肥大细胞和P物质在扁平苔藓的发病中可能起一定的作用。
Objective： To determine the role of mast cells and substance P in the pathogenesis of hchen planus. Methods： The number of undegranulated mast cells and the expression level of substance P were detected in the lesions of lichen planus by histochemical and immunohistochemical technique. Results： Compared with normal controis, the number of undegranulated mast cells in lichen planus lesions was significantly lower （ P 〈 0.01 ）, while the expression level of substance P was significantly higher （ P 〈 0.01 ）. There was a negative correlation between the number of undegranulated mast cells and the expression of substance P in the lesions of hchen planus （ rs = -0. 397, P 〈 0.05）. Conclusion： Mast cells and substance P might play a certain role in the pathogenesis of lichen planus.
出处
《中国麻风皮肤病杂志》
2006年第8期630-632,共3页
China Journal of Leprosy and Skin Diseases
作者简介
通讯作者
