摘要
本实验观察大剂量雌二醇对大鼠血压的影响，用放射免疫方法检测生长抑素含量变化。结果表明：腹腔大剂量注射雌二醇显著提高大鼠血压。在雌二醇诱发高血压的过程中，下丘脑，延髓，脑垂体、肾上腺中生长抑素的含量明显减少，血浆生长抑素的含量显著提高（Ｐ＜０．０５～ｐ＜０．０１）。提示生长抑素水平的变化参与雌二醇诱发高血压过程。
The effects of high-dose estradiol (E2) administrated on blood pressure (BP) was observedand the contents of somatostatin(SS)in plasma,medulla oblongata,hypothalamus,pituitacy andadrenal wrre measured by radioimmunoassay(RIA)。The results;showed that(1)High-doseE2 administrated could euhence the BP significantly. (2)After high-dose E2 treatment the ss con-tents in hypothalamus, medulla oblongata, pitintary and adienal were decreased signifcantiy(P<0.05～0.001),but the SS content in plasma wasmarkly increased(P<0.05)as compared with con-trol group.These results indicatal that changes of SS contents in plasma and some tissues were re-lated to the process of hypertension induced by high-dose E2.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1996年第2期149-154,共6页
Chinese Journal of Pathophysiology
关键词
雌二醇
生长抑素
血压
剂量
Estiadiol·Blood pressure·Somatostatin
