摘要
目的观察杭白芷香豆素组分(CAD)的解热镇痛抗炎作用。方法采用大鼠酵母致热法观察其解热作用,用小鼠扭体法和热板法观察其镇痛作用,用小鼠耳廓肿胀法和大鼠足跖肿胀法观察其抗炎作用。结果CAD对酵母引起的大鼠发热有显著解热作用;对热板所致小鼠疼痛和醋酸所致小鼠扭体反应均有显著抑制作用;并能对抗二甲苯所致的小鼠耳肿胀和蛋清所致的大鼠足肿胀。结论CAD具有显著的解热镇痛抗炎作用。
Objective To observe the antipyretic-analgesic and anti-inflammatory effects of total coumarins from Radix Angelicae Dahurica （CAD）. Method The rat febrile models were induced by injecting dry yeast subcutaneously. The pain models were established by acetic acid and hot plate in mice. The mouse and rat inflammatory models were caused with dimethylbenzene （auricle smear method） and egg white （injection under the aponeurosis） respectively. Result CAD depressed the fervescence by yeast effectively in rat, inhibited the pain caused by acetic acid and hot plate evidently in mice. At the same time, it was found that the mouse＇s ear edema induced by dimethylbenzene and the rat＇s hind paw edema induced by egg white were all significantly suppressed by CAD. Conclusion CAD has notable antipyretic-analgesic and anti-inflammatory effects.
出处
《中国中医药信息杂志》
CAS
CSCD
2005年第11期36-37,52,共3页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
杭白芷
香豆素类
解热
镇痛
抗炎
Radix Angelicae Dahurica
coumarins
pyretolysis
analgesia
anti-inflammation
