摘要
目的:探讨细胞免疫与复发性阿弗它溃疡(recurrent aphthous u lcer,RAU)发病机制的关系及茶多酚(teapolyphenols,TP)对RAU的免疫调节作用。方法:用免疫方法建立SD大鼠RAU动物模型,将RAU大鼠随机分成阴性对照组、溃疡糊剂组和3个TP治疗组。用流式细胞仪检测成模前后及用药前后各组大鼠外周血T淋巴细胞亚群CD4+、CD8+细胞数量及比值。结果:实验大鼠溃疡模型成模后外周血CD4+及CD4+/CD8+较成模前显著降低(P<0.01),CD8+改变无统计学意义(P>0.05)。茶多酚各治疗组外周血CD4+、CD4+/CD8+回升,与阴性对照组有显著性差异(P<0.05),茶多酚各治疗组间比较没有显著性差异(P>0.05)。结论:RAU的发生与细胞免疫功能抑制有关,TP对大鼠RAU具有免疫调节作用,其免疫调节作用与给药方式无关。
Objective： To observe the relationship between cellular immune and the pathogenesis of recurrent aphthous ulcer （ RAU ） and to evaluate the immune regulation of tea polyphenols （TP） on RAU. Methods： RAU models were established by injecting antigens into SD rats. Five groups, including control group, ulcer cataplasm group and three TP therapeutic groups, were divided randomly. The changes of CD4^＋ and CD8^＋ values in blood were measured by flow cytometry （FCM）. Results： Compared with normal group, the values of CD4^＋ and CD4^＋/CD8^＋ showed significantly lower level in RAU rats （P 〈0.01 ）, while CD8^＋ not（ P 〉 0.05）. After TP treatment, the values of CD4^＋ and CD4^＋/CD8^＋ increased significantly （ P 〈 0.05 ）. It did not show any significant difference among three TP therapeutic groups （ P 〉 0.05 ）. Conclusion ： The inhibition of cellular immune function may contribute to RAU incidence ; TP had the immune regulation on experimental RAU rats, which wasn＇ t related to the way of administration in this experiment.
出处
《口腔医学研究》
CAS
CSCD
2005年第4期393-395,共3页
Journal of Oral Science Research
基金
贵州省卫生厅基金资助项目
作者简介
梁文红（1968-），女，陕西人，主治医师，硕士研究生，主要从事龋病，黏膜病的防治工作。
刘建国，电话：（0852）8635719
