摘要
观察了２０例急性心肌梗塞（ＡＭＩ）患者血小板数目和血小板膜表面小颗粒膜蛋白（ＧＭＰ－１４０）水平的动态变化，并与血清心肌型肌酸激酶同功酶（ＣＫ－ＭＢ）活性进行了相关分析。结果显示，ＡＭＩ时血小板数目明显减少，尤以发病后的第２天最为显著，血小板膜表面ＧＭＰ－１４０分子数在ＡＭＩ早期明显增高，第２天达高峰。两者均在５～７天恢复正常；血清ＣＫ－ＭＢ活性增高与血小板数目减少呈负相关（ｒ＝－０．６１２３，Ｐ＜０．００５）、与血小板膜表面ＧＭＰ－１４０水平升高呈正相关（ｒ＝０．５８９５，Ｐ＜０．０１）。ＡＭＩ伴泵衰谒，死亡者血小板数目减少更为显著，表明血小板直接参与了心肌梗塞的病理过程。
latelet number and alpha-granule membtane protein (GMP-140)level platelet surface were deter-mined in 20 patients wIth acute mvocardial infarction(AMI)and 20 norn1al subjects.The results showed that platelet nulnber decrea8ed significantly after AMI,especially on the second day after onset and that the level of GMP-140 increased rapluly after AMI and reached a peak on the second after the attack.Both returned to the normal on the 5～7th day after the heart attack.CorreIative analysis between increase of serum CK- MB and plateIet number was negative (r=-0.6123,P<0. 005),and positive between that and GMPI40 1evel (r =-0. 5895.P<0.01).PlateIet number decreased markedlv in cases with heart fai-lure and cardiac death.The results indicate that platelets are involvdin the pathological process of AMI.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第1期19-21,共3页
Chinese Journal of Internal Medicine
