摘要
研究了用2-氯乙基甲醚和3-氨基-4-甲氧基乙酰苯胺合成标题化合物的反应条件。发现反应的主要因素在于反应过程中PH值和温度的控制。在整个反应过程中用缓冲溶液体系控制PH为5.5—6.5的条件下,反应温度为125℃左右分批加入2-氮乙基甲醚可得到收率大于91%、GC含量大于98%的产品。
The process for preparing N-[3-(Bis(2-methoxyethyl)amino)-4-methoxy] Acetanilide from 2-chloroethyl methyl ether and 3-amino-4-methoxy acetanilide was studied. It was found that the main influential factors for the reaction were the pH of the solution and the reaction temperature. Under the optimum reaction conditions as controlling the pH about 5.5~6.5 by buffer solution, reaction temperature about 125℃, and adding 2-chloroethyl methyl ether slowly in the process, the yield of product was above 91% with a purity of larger than 98%(GC).
出处
《染料与染色》
CAS
2005年第3期47-50,共4页
Dyestuffs and Coloration
