摘要
肿瘤血管生成是肿瘤生长转移的关键步骤,是促血管生成因子和抑制因子作用失衡的结果。以肿瘤血管生成为靶点的抗血管生成治疗作为肿瘤治疗新视野,已发展为重要的抗癌策略。基因治疗则使抗血管生成治疗更具有靶向性,使这一治疗策略产生新的飞跃。作者就该领域研究进展作一综述。
Tumor angiogenesis, resulting from the imbalance of angiogenic cytokines and angiogenesis inhibitors, is crucial for tumor growth and metastasis. As a new field of cancer therapy, tumor anti-angiogenesis therapy with regard to abrogation of tumor vasculature has become an important anti-tumor strategy. Gene therapies have the potential to provide antiangiogenic mediators specifically targeted to organs containing tumors and make a great improvement in this therapy. This article reviews the current understanding of tumor angiogenesis, with a focus on gene therapy in this field.
出处
《医学研究生学报》
CAS
2005年第6期559-563,共5页
Journal of Medical Postgraduates
