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WNT信号转导在肝细胞癌发病中的作用 被引量：5

Role of Wnt signaling pathway in hepatocellular carcinoma
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摘要 Wnt蛋白及其受体、调节蛋白等一起组成了复杂的信号通路,它与胚胎正常发育、细胞的增殖与分化以及肿瘤形成密切相关。Wnt信号通路与肝细胞癌的关系,近年来受到广泛关注,得到了深入的研究。作者就W nt信号通路及其调节蛋白之间相互作用,Wnt信号通路与肝细胞癌发生发展、血管形成、侵袭和转移等方面的关系作一综述。 Wnt proteins, its receptors and regulators compose complex signaling pathways which are closely related to embryonic development, cell proliferation and differentiation, as well as tumour generation. In recent years, the involvement of Wnt signaling pathways in hepatocarcinogenesis has drawn the attention of international medical circles and been studied intensively. In this review, we summaries the interaction between Wnt signaling pathways and its regulators, the relationship between Wnt signaling pathways and cancerogenesis, angiogenesis, invasion and metabasis in hepatocellular carcinoma.
作者 吴龙 钱叶本
机构地区 安徽医科大学第一附属医院肝胆外科
出处 《医学研究生学报》 CAS 2007年第6期651-655,共5页 Journal of Medical Postgraduates
基金 安徽省教育厅自然科学基金资助项目(批准号:2006KJ094A)
关键词 WNT信号通路 肝细胞癌 血管生成 侵袭 转移 Wnt signaling pathways Hepatocellular carcinoma Angiogenesis Invasion Metabasis
分类号 R735.7 [医药卫生—肿瘤]
作者简介 吴龙（1965-），男，安徽枞阳人，主治医师，医学硕士研究生，从事肝胆外科专业。 通讯作者：钱叶本（1965-），男，安徽枞阳人，教授，主任医师，医学博士，从事肝胆外科专业。
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参考文献26

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二级参考文献44

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共引文献14

同被引文献44

引证文献5

二级引证文献9

医学研究生学报
2007年 第6期

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