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血管紧张素转化酶抑制剂抗肿瘤作用的研究进展 被引量:6

Anti-tumor activity of angiotensin-converting-enzyme inhibitors
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摘要 血管紧张素转化酶抑制剂(ACEI)类药物是临床心脑血管系统常用药物,一些流行病学研究发现其具有抗肿瘤作用。研究表明ACEI类药物具有抑制肿瘤发生、生长,抗肿瘤血管生成,抑制细胞外基质降解和治疗恶病质等多种作用。作者就其最新研究进展综述如下。 Angiotensin-converting-enzyme inhibitors (ACEI) are generally used in the treatment of cardiovascular system diseases. They are found by epidemiological studies to have an anti-tumor activity and are shown to play various roles in suppressing carcinogenesis and tumor growth, preventing angiogenesis, inhibiting matrix degradation and reducing cancer cachexia.
出处 《医学研究生学报》 CAS 2008年第3期325-329,共5页 Journal of Medical Postgraduates
基金 南京军区南京总医院科研基金资助项目(批准号:2005019)
关键词 血管紧张素转化酶抑制剂 肿瘤 抗肿瘤血管生成 细胞外基质 恶病质 Angiotensin-converting-enzyme inhibitors Tumor Antiangiogenesis Extracellular matrix Cachexia
作者简介 许小兵(1980-),男,江苏如皋人,医学硕士研究生,从事消化内科专业。
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  • 1Piepho RW. Overview of the angiotensin-converting-enzyme inhibitors [ J ]. Am J Health-Syst Pharm,2000,57 ( 10 ) : S3-7.
  • 2Lever AF,Hole DJ,Gillis CR,et al. Do inhibitors of angiotensin-coverting enzyme protect against risk of cancer? [ J ] Lancet, 1998,352 (9123) : 179-184.
  • 3Ronquist G, Rodriguez LA, Ruigomez A, et al. Association between captopril, other antihypertensive drugs and risk of prostate cancer[J]. Prostate,2004,58( 1 ) :50-56.
  • 4Koh WP, Yuan JM, Sun CL, et al. Angiotensin 1-converting enzyme( ACE )gene polymorphism and breast cancer risk among Chinese women in Singapore [ J ]. Cancer Res,2003,63 ( 3 ) :573- 578.
  • 5Medeiros R, Vasconcelos A, Costa S, et al. Linkage of angiotensin 1-converting enzyme gene insertion/deletion polymorphism to the progression of human prostate cancer [ J ]. J Pathol, 2004,202 (3) :330-335.
  • 6Rocken C, Lendeckel U, Dierkes J, et al. The number of lymph node metastases in gastric cancer correlates with the angiotensin 1-converting enzyme gene insertion/deletion polymorphism [ J ]. Clin Cancer Res,2005,11 (7) :2526-2530.
  • 7Gonzalez-Zuloeta Ladd AM, Vasquez AA, Sayed-Tabatabaei FA, et al. Angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk [ J ]. Cancer Epidemiol Biomarkers Prey,2005,14(9) :2143-2146.
  • 8Chen L, Re RN, Prakash O, et al. Angiotensin-converting-enzyme inhibition reduces neuroblastoma cell growth rate [ J ]. Proc Soc Expt Bio Med, 1991,196 ( 3 ) :280-283.
  • 9Reddy MK, Baskaran K, Molteni A. Inhibitors of angiotensin convening enzyme modulate mitosis and gene expression in pancreatic cancer cells[J]. Proc Soc Expt Biol Med,1995,210(3) :221- 226.
  • 10Small Jr W, Molteni A, Kim JT, et al. Captopril modulates hormone receptor concentration and inhibits proliferation of human mammary ductal, carcinoma cells in culture [ J ]. Breast Cancer Res Treat, 1997,44(3 ) :217-224.

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