摘要
目的:观察牛磺酸对蟾蜍坐骨神经干兴奋性的影响。方法:分离蟾蜍的坐骨神经干(5 0根) ,分5组,用含不同浓度CaCl2 和牛磺酸的任氏液浸泡30min备用。用Medlab生物信号采集处理系统测定神经干的阈值、不应期和传导速度。结果:与正常任氏液(1.0 9mmol/L)比较,高钙任氏液(2 .18mmol/L)神经干的阈值升高,不应期缩短(P <0 .0 1) ;低钙任氏液(0 .2 7mmol/L)的神经干的阈值降低,不应期缩短,传导速度加快(P <0 .0 5～P <0 .0 1) ;而低钙加牛磺酸组及高钙加牛磺酸(40mmol/L)组上述变化均不明显(P >0 .0 5 )。
Objective:To observe the effect of taurine on the excitation of the sciatic nerve trunk in vitro.Methods:The sciatic nerve trunks of toads were isolated and soaked in Ringer’s solution containing different concentration of chloride calcium with taurine(40 mmol/L) for 30 minutes.The threshold,refractory period and conduction velocities of action potential were measured by computer.Results:Compared with the normal Ringer’s solution group (1.09 mmol/L),the threshold increased and the refractory period shrinked in the Ringer’s solution containing higher concentration of chloride calcium(2.18 mmol/L),while the threshold and the conduction velocity of action potential decreased,the refractory period shrinked in the lower concentration(0.27 mmol/L)(P<0.05-P<0.01).Above changes are unobvious in Ringer’s solution containing taurine(40 mmol/L) with lower or higher concentration of chloride calcium(P>0.05).Conclusions:The taurine could regulate the excitability of the sciatic nerve trunk in vitro.
出处
《蚌埠医学院学报》
CAS
2005年第3期226-227,共2页
Journal of Bengbu Medical College
关键词
神经传导
牛磺酸
氯化钙
蟾蜍
动作电位
阈值
neural conduction
taurine toad
chloride calcium
toad action potentials
threshold
