摘要
目的研究胃癌细胞MMP2、MMP9和TIMP1的表达与淋巴结转移及生存时间的关系。方法用免疫组织化学方法检测136例胃腺癌组织微阵列中MMP2、MMP9和TIMP1的表达。结果MMP9在淋巴结有转移病例中阳性率为76%,与淋巴结转移程度相关(P=0.0228);N分期和胃癌病人术后生存时间相关(P<0.0001)。结论胃癌细胞中MMP9阳性可作为预测胃癌淋巴结转移程度的分子标志物,N分期是预测胃癌病人术后生存时间的病理学指标。
Objective To study the expression of MMP-2, MMP-9 and TIMP-1 in gastric adenocarcinoma.Methods Tissue microarray of 136 gastric adenocarcinoma was constructed by using a microarrayer.The expression of MMP-2,MMP-9 and TIMP-1 was detected on the section of tissue microarray by immunohistochemistry.Results The positive rate of the expression of MMP-9 was 76% in gastric adenocarcinoma and was related to the magnitude of lymph node metastasis. N staging is related to survival time of gastric adenocarcinoma.Conclusion Overexpression of MMP-9 is likely to a marker of lymph node metastasis in gastric adenocarcinoma. N staging is a pathological parameter in survival time of gastric adenocarcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2005年第5期274-275,共2页
Cancer Research on Prevention and Treatment
基金
武汉市科技局科技攻关计划引导项目(20025007170)
