摘要
目的分析乳腺癌CerbB-2的表达与年龄、肿瘤大小、病理学类型、腋窝淋巴结转移及远处转移的相关性。方法应用免疫组化sP法对69例原发性乳腺癌行根治及改良根治术的标本进行了CerbB-2的检测，并进行统计学分析。结果CerbB-2阳性表达率为73．9％（51／69）；CerbB-2的阳性表达率与淋巴结转移及有远处转移有关（P〈0．05），而与患者年龄、肿瘤大小、病理学类型无关（P〉0．05）。结论CerbB-2的阳性表达与淋巴结转移程度呈正相关，与年龄、肿瘤大小、病理学类型及远处转移不相关。CerbB-2的过表达与淋巴结转移及远处转移相关。CerbB-2可作为判断乳腺癌预后的指标。
Objective To investigate the relationship between the expression of CerbB-2 in breast cancer and the age, tumor size, patho!ogical type of cancer and lymphnode metastasis and other organ metastasis in breast cancer patients. Methods Immunohistochemical SP method was used for the detection of CerbB-2 in specimens taken from 69 breast cancer patients undergoing radical treatment or modified radical treatment. χ^2 Statistical analysis was used. Results The positive expression rates of CerbB-2 were 73.9% （51/69） （ ＋ 34. 8%, ＋ ＋ 10. 1%, ＋ ＋ ＋ 29. 0% ）, and the positive expression rates of them were associated with lymph node metastasis （P 〈 0. 05 ）, but not related to patient＇ s age, tumor size, histologicahype and other organ metas- tasis（ P 〉 0.05 ）. The overexpression of CerbB-2 were associated with lymph node metastasis and other organ metastasis. Conclusion The positive expression rates of CerbB-2 were related to lymph node metastasis, but not related to patient＇ s age, tumor size and histological type. They can be used to predict the prognosis of breast cancer patients.
出处
《中国临床实用医学》
2010年第1期14-15,共2页
China Clinical Practical Medicine
