摘要
目的:考察酸枣仁总生物碱对小鼠的镇静催眠作用。方法:采用镇静催眠观察对小鼠自主活动,协同戊巴比妥钠对小鼠睡眠作用的影响。结果:酸枣仁总生物碱(25～100mg/kg)灌胃可减少小鼠自发活动,显著延长阈上剂量戊巴比妥钠致小鼠睡眠时间,增加阈下剂量戊巴比妥钠睡眠动物数。结论:提示生物碱为酸枣仁中枢抑制作用的有效部位。
Objective: In this paper the sedative and hyponotic effects of total alkaloids were studied. Methods: sedative and hyponotic as well as anticonvulsant experiments were made to observe the effect of total alkaloid from semen zizyphi spinosae on the spontaneous motion and hyponosis in mice. Results: The result showed that total alkaloid from Semen Zizyphi Spinosae could markedly inhibit spontaneous motion,enhance the sleeping number of pentobarbital sodium (subthreshold dosage; and prolong the sleeping time of pentobarbital sodium (superthreshold dosage;. Conclusion: The total alkaloid from Semen Zizyphi Spinosae possesses obvious sedative and hyponotic effects.
出处
《天津医科大学学报》
2005年第1期52-54,共3页
Journal of Tianjin Medical University
关键词
酸枣仁
总生物碱
镇静催眠
Semen Zizyphi Spinosae
Total alkaloid
Sedation and hyponosis
